Synthesis of New Cisplatin Derivatives from Bile Acids

A series of bile acid derived 1,2- and 1,3-diamines as well as their platinum(II) complexes were designed and synthesized in hope to get a highly cytotoxic compound by the combination of two bioactive moieties. All complexes obtained were subjected to cytotoxicity assays in vitro and some hybrid mol...

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Autores principales: Seroka, Barbara, Łotowski, Zenon, Hryniewicka, Agnieszka, Rárová, Lucie, R. Sicinski, Rafal, M. Tomkiel, Aneta, W. Morzycki, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036801/
https://www.ncbi.nlm.nih.gov/pubmed/32033039
http://dx.doi.org/10.3390/molecules25030655
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author Seroka, Barbara
Łotowski, Zenon
Hryniewicka, Agnieszka
Rárová, Lucie
R. Sicinski, Rafal
M. Tomkiel, Aneta
W. Morzycki, Jacek
author_facet Seroka, Barbara
Łotowski, Zenon
Hryniewicka, Agnieszka
Rárová, Lucie
R. Sicinski, Rafal
M. Tomkiel, Aneta
W. Morzycki, Jacek
author_sort Seroka, Barbara
collection PubMed
description A series of bile acid derived 1,2- and 1,3-diamines as well as their platinum(II) complexes were designed and synthesized in hope to get a highly cytotoxic compound by the combination of two bioactive moieties. All complexes obtained were subjected to cytotoxicity assays in vitro and some hybrid molecules showed an expected activity.
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spelling pubmed-70368012020-03-11 Synthesis of New Cisplatin Derivatives from Bile Acids Seroka, Barbara Łotowski, Zenon Hryniewicka, Agnieszka Rárová, Lucie R. Sicinski, Rafal M. Tomkiel, Aneta W. Morzycki, Jacek Molecules Article A series of bile acid derived 1,2- and 1,3-diamines as well as their platinum(II) complexes were designed and synthesized in hope to get a highly cytotoxic compound by the combination of two bioactive moieties. All complexes obtained were subjected to cytotoxicity assays in vitro and some hybrid molecules showed an expected activity. MDPI 2020-02-04 /pmc/articles/PMC7036801/ /pubmed/32033039 http://dx.doi.org/10.3390/molecules25030655 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Seroka, Barbara
Łotowski, Zenon
Hryniewicka, Agnieszka
Rárová, Lucie
R. Sicinski, Rafal
M. Tomkiel, Aneta
W. Morzycki, Jacek
Synthesis of New Cisplatin Derivatives from Bile Acids
title Synthesis of New Cisplatin Derivatives from Bile Acids
title_full Synthesis of New Cisplatin Derivatives from Bile Acids
title_fullStr Synthesis of New Cisplatin Derivatives from Bile Acids
title_full_unstemmed Synthesis of New Cisplatin Derivatives from Bile Acids
title_short Synthesis of New Cisplatin Derivatives from Bile Acids
title_sort synthesis of new cisplatin derivatives from bile acids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036801/
https://www.ncbi.nlm.nih.gov/pubmed/32033039
http://dx.doi.org/10.3390/molecules25030655
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