Elucidating Binding Sites and Affinities of ERα Agonists and Antagonists to Human Alpha-Fetoprotein by In Silico Modeling and Point Mutagenesis

Alpha-fetoprotein (AFP) is a major embryo- and tumor-associated protein capable of binding and transporting a variety of hydrophobic ligands, including estrogens. AFP has been shown to inhibit estrogen receptor (ER)-positive tumor growth, which can be attributed to its estrogen-binding ability. Desp...

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Detalles Bibliográficos
Autores principales: Moldogazieva, Nurbubu T., Ostroverkhova, Daria S., Kuzmich, Nikolai N., Kadochnikov, Vladimir V., Terentiev, Alexander A., Porozov, Yuri B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036865/
https://www.ncbi.nlm.nih.gov/pubmed/32019136
http://dx.doi.org/10.3390/ijms21030893

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036865/
https://www.ncbi.nlm.nih.gov/pubmed/32019136
http://dx.doi.org/10.3390/ijms21030893

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