Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies

Genetic ablation as well as pharmacological inhibition of sirtuin 2 (SIRT2), an NAD(+)-dependent protein deacylase, have therapeutic effects in various cancers and neurodegenerative diseases. Previously, we described the discovery of a dual SIRT1/SIRT2 inhibitor called cambinol (IC(50) 56 and 59 µM,...

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Detalles Bibliográficos
Autores principales: Chowdhury, Sarwat, Sripathy, Smitha, Webster, Alyssa A., Park, Angela, Lao, Uyen, Hsu, Joanne H., Loe, Taylor, Bedalov, Antonio, Simon, Julian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036909/
https://www.ncbi.nlm.nih.gov/pubmed/31973227
http://dx.doi.org/10.3390/molecules25030455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036909/
https://www.ncbi.nlm.nih.gov/pubmed/31973227
http://dx.doi.org/10.3390/molecules25030455

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