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Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies
Genetic ablation as well as pharmacological inhibition of sirtuin 2 (SIRT2), an NAD(+)-dependent protein deacylase, have therapeutic effects in various cancers and neurodegenerative diseases. Previously, we described the discovery of a dual SIRT1/SIRT2 inhibitor called cambinol (IC(50) 56 and 59 µM,...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036909/ https://www.ncbi.nlm.nih.gov/pubmed/31973227 http://dx.doi.org/10.3390/molecules25030455 |