A Dietary Ketone Ester Normalizes Abnormal Behavior in a Mouse Model of Alzheimer’s Disease

Because of a decreased sensitivity toward insulin, a key regulator of pyruvate dehydrogenase (PDH), Alzheimer’s patients have lower brain glucose utilization with reductions in Tricarboxylic Acid (TCA) cycle metabolites such as citrate, a precursor to n-acetyl-aspartate. In the 3xTgAd mouse model of...

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Detalles Bibliográficos
Autores principales: Pawlosky, Robert J., Kashiwaya, Yoshihero, King, M. Todd, Veech, Richard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036949/
https://www.ncbi.nlm.nih.gov/pubmed/32033248
http://dx.doi.org/10.3390/ijms21031044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036949/
https://www.ncbi.nlm.nih.gov/pubmed/32033248
http://dx.doi.org/10.3390/ijms21031044

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