The Amuvatinib Derivative, N-(2H-1,3-Benzodioxol-5-yl)-4-{thieno[3,2-d]pyrimidin-4-yl}piperazine-1-carboxamide, Inhibits Mitochondria and Kills Tumor Cells under Glucose Starvation

Glucose levels inside solid tumors are low as compared with normal surrounding tissue, forcing tumor cells to reprogram their metabolism to adapt to such low glucose conditions. Unlike normal tissue, tumor cells experience glucose starvation, making the targeting of pathways supporting survival duri...

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Detalles Bibliográficos
Autores principales: Marciano, Ran, Ben David, Hila, Akabayov, Barak, Rotblat, Barak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036964/
https://www.ncbi.nlm.nih.gov/pubmed/32033217
http://dx.doi.org/10.3390/ijms21031041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036964/
https://www.ncbi.nlm.nih.gov/pubmed/32033217
http://dx.doi.org/10.3390/ijms21031041

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