Transgenic Mice Overexpressing Human STIM2 and ORAI1 in Neurons Exhibit Changes in Behavior and Calcium Homeostasis but Show No Signs of Neurodegeneration

The maintenance of proper cytosolic Ca(2+) level is crucial for neuronal survival, and dysregulation of Ca(2+) homeostasis is found in a variety of neurological disorders, including Alzheimer’s disease. According to the “Ca(2+) hypothesis of aging”, Ca(2+) disturbances precede the onset of AD sympto...

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Detalles Bibliográficos
Autores principales: Majewski, Lukasz, Maciąg, Filip, Boguszewski, Pawel M., Kuznicki, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037127/
https://www.ncbi.nlm.nih.gov/pubmed/32012922
http://dx.doi.org/10.3390/ijms21030842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037127/
https://www.ncbi.nlm.nih.gov/pubmed/32012922
http://dx.doi.org/10.3390/ijms21030842

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