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Transgenic Mice Overexpressing Human STIM2 and ORAI1 in Neurons Exhibit Changes in Behavior and Calcium Homeostasis but Show No Signs of Neurodegeneration
The maintenance of proper cytosolic Ca(2+) level is crucial for neuronal survival, and dysregulation of Ca(2+) homeostasis is found in a variety of neurological disorders, including Alzheimer’s disease. According to the “Ca(2+) hypothesis of aging”, Ca(2+) disturbances precede the onset of AD sympto...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037127/ https://www.ncbi.nlm.nih.gov/pubmed/32012922 http://dx.doi.org/10.3390/ijms21030842 |