Pharmacokinetic Characterization and Tissue Distribution of Fusion Protein Therapeutics by Orthogonal Bioanalytical Assays and Minimal PBPK Modeling

Characterization of pharmacokinetic (PK) properties and target tissue distribution of therapeutic fusion proteins (TFPs) are critical in supporting in vivo efficacy. We evaluated the pharmacokinetic profile of an investigational TFP consisting of human immunoglobulin G4 fused to the modified interfe...

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Detalles Bibliográficos
Autores principales: Sugimoto, Hiroshi, Chen, Susan, Qian, Mark G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037219/
https://www.ncbi.nlm.nih.gov/pubmed/31991858
http://dx.doi.org/10.3390/molecules25030535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037219/
https://www.ncbi.nlm.nih.gov/pubmed/31991858
http://dx.doi.org/10.3390/molecules25030535

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