AP-1 activity induced by co-stimulation is required for chromatin opening during T cell activation

Activation of T cells is dependent on the organized and timely opening and closing of chromatin. Herein, we identify AP-1 as the transcription factor that directs most of this remodeling. Chromatin accessibility profiling showed quick opening of closed chromatin in naive T cells within 5 h of activa...

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Detalles Bibliográficos
Autores principales: Yukawa, Masashi, Jagannathan, Sajjeev, Vallabh, Sushmitha, Kartashov, Andrey V., Chen, Xiaoting, Weirauch, Matthew T., Barski, Artem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037242/
https://www.ncbi.nlm.nih.gov/pubmed/31653690
http://dx.doi.org/10.1084/jem.20182009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037242/
https://www.ncbi.nlm.nih.gov/pubmed/31653690
http://dx.doi.org/10.1084/jem.20182009

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