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AP-1 activity induced by co-stimulation is required for chromatin opening during T cell activation
Activation of T cells is dependent on the organized and timely opening and closing of chromatin. Herein, we identify AP-1 as the transcription factor that directs most of this remodeling. Chromatin accessibility profiling showed quick opening of closed chromatin in naive T cells within 5 h of activa...
Autores principales: | Yukawa, Masashi, Jagannathan, Sajjeev, Vallabh, Sushmitha, Kartashov, Andrey V., Chen, Xiaoting, Weirauch, Matthew T., Barski, Artem |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037242/ https://www.ncbi.nlm.nih.gov/pubmed/31653690 http://dx.doi.org/10.1084/jem.20182009 |
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