Innovative Three-Step Microwave-Promoted Synthesis of N-Propargyltetrahydroquinoline and 1,2,3-Triazole Derivatives as a Potential Factor Xa (FXa) Inhibitors: Drug Design, Synthesis, and Biological Evaluation

The coagulation cascade is the process of the conversion of soluble fibrinogen to insoluble fibrin that terminates in production of a clot. Factor Xa (FXa) is a serine protease involved in the blood coagulation cascade. Moreover, FXa plays a vital role in the enzymatic sequence which ends with the t...

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Detalles Bibliográficos
Autores principales: Santana-Romo, Fabián, Lagos, Carlos F., Duarte, Yorley, Castillo, Francisco, Moglie, Yanina, Maestro, Miguel A., Charbe, Nitin, Zacconi, Flavia C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037264/
https://www.ncbi.nlm.nih.gov/pubmed/31979319
http://dx.doi.org/10.3390/molecules25030491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037264/
https://www.ncbi.nlm.nih.gov/pubmed/31979319
http://dx.doi.org/10.3390/molecules25030491

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