Disruption of the Unique ABCG-Family NBD:NBD Interface Impacts Both Drug Transport and ATP Hydrolysis

ABCG2 is one of a triumvirate of human multidrug ATP binding cassette (ABC) transporters that are implicated in the defense of cells and tissues against cytotoxic chemicals, but these transporters can also confer chemotherapy resistance states in oncology. Understanding the mechanism of ABCG2 is thu...

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Detalles Bibliográficos
Autores principales: Kapoor, Parth, Briggs, Deborah A., Cox, Megan H., Kerr, Ian D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037313/
https://www.ncbi.nlm.nih.gov/pubmed/31979415
http://dx.doi.org/10.3390/ijms21030759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037313/
https://www.ncbi.nlm.nih.gov/pubmed/31979415
http://dx.doi.org/10.3390/ijms21030759

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