Constitutive Activation of Guanylate Cyclase by the G86R GCAP1 Variant Is Due to “Locking” Cation-π Interactions that Impair the Activator-to-Inhibitor Structural Transition

Guanylate Cyclase activating protein 1 (GCAP1) mediates the Ca(2+)-dependent regulation of the retinal Guanylate Cyclase (GC) in photoreceptors, acting as a target inhibitor at high [Ca(2+)] and as an activator at low [Ca(2+)]. Recently, a novel missense mutation (G86R) was found in GUCA1A, the gene...

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Detalles Bibliográficos
Autores principales: Abbas, Seher, Marino, Valerio, Bielefeld, Laura, Koch, Karl-Wilhelm, Dell’Orco, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037459/
https://www.ncbi.nlm.nih.gov/pubmed/31979372
http://dx.doi.org/10.3390/ijms21030752

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037459/
https://www.ncbi.nlm.nih.gov/pubmed/31979372
http://dx.doi.org/10.3390/ijms21030752

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