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Constitutive Activation of Guanylate Cyclase by the G86R GCAP1 Variant Is Due to “Locking” Cation-π Interactions that Impair the Activator-to-Inhibitor Structural Transition
Guanylate Cyclase activating protein 1 (GCAP1) mediates the Ca(2+)-dependent regulation of the retinal Guanylate Cyclase (GC) in photoreceptors, acting as a target inhibitor at high [Ca(2+)] and as an activator at low [Ca(2+)]. Recently, a novel missense mutation (G86R) was found in GUCA1A, the gene...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037459/ https://www.ncbi.nlm.nih.gov/pubmed/31979372 http://dx.doi.org/10.3390/ijms21030752 |