Development of RNA/DNA Hydrogel Targeting Toll-Like Receptor 7/8 for Sustained RNA Release and Potent Immune Activation

Guanosine- and uridine-rich single-stranded RNA (GU-rich RNA) is an agonist of Toll-like receptor (TLR) 7 and TLR8 and induces strong immune responses. A nanostructured GU-rich RNA/DNA assembly prepared using DNA nanotechnology can be used as an adjuvant capable of improving the biological stability...

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Detalles Bibliográficos
Autores principales: Komura, Fusae, Okuzumi, Kana, Takahashi, Yuki, Takakura, Yoshinobu, Nishikawa, Makiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037604/
https://www.ncbi.nlm.nih.gov/pubmed/32046113
http://dx.doi.org/10.3390/molecules25030728

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037604/
https://www.ncbi.nlm.nih.gov/pubmed/32046113
http://dx.doi.org/10.3390/molecules25030728

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