Novel Cationic Prodrug of Ubiquinol-10 Enhances Intestinal Absorption via Efficient Formation of Nanosized Mixed-Micelles with Bile Acid Anions

The aim of this study was to develop a prodrug of ubiquinol-10 (UqH-10), the active form of ubiquinone-10 (Uq-10), for oral delivery. Bioavailability of UqH-10 is hampered by its high susceptibility to oxidation and water-insolubility. We prepared three novel N,N-dimethylglycine ester derivatives of...

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Detalles Bibliográficos
Autores principales: Setoguchi, Shuichi, Hidaka, Ryoji, Nagata-Akaho, Nami, Watase, Daisuke, Koga, Mitsuhisa, Matsunaga, Kazuhisa, Karube, Yoshiharu, Takata, Jiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037610/
https://www.ncbi.nlm.nih.gov/pubmed/32012733
http://dx.doi.org/10.3390/molecules25030546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037610/
https://www.ncbi.nlm.nih.gov/pubmed/32012733
http://dx.doi.org/10.3390/molecules25030546

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