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Candidate SNP Markers of Atherogenesis Significantly Shifting the Affinity of TATA-Binding Protein for Human Gene Promoters Show Stabilizing Natural Selection as a Sum of Neutral Drift Accelerating Atherogenesis and Directional Natural Selection Slowing It
(1) Background: The World Health Organization (WHO) regards atherosclerosis-related myocardial infarction and stroke as the main causes of death in humans. Susceptibility to atherogenesis-associated diseases is caused by single-nucleotide polymorphisms (SNPs). (2) Methods: Using our previously devel...
Autores principales: | Ponomarenko, Mikhail, Rasskazov, Dmitry, Chadaeva, Irina, Sharypova, Ekaterina, Drachkova, Irina, Oshchepkov, Dmitry, Ponomarenko, Petr, Savinkova, Ludmila, Oshchepkova, Evgeniya, Nazarenko, Maria, Kolchanov, Nikolay |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037642/ https://www.ncbi.nlm.nih.gov/pubmed/32033288 http://dx.doi.org/10.3390/ijms21031045 |
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