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Exploration of Mechanochemical Activation in Solid-State Fluoro-Grignard Reactions

Owing to the strength of the C–F bond, the ‘direct’ preparation of Grignard reagents, i.e., the interaction of elemental magnesium with an organic halide, typically in an ethereal solvent, fails for bulk magnesium and organofluorine compounds. Previously described mechanochemical methods for prepari...

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Detalles Bibliográficos
Autores principales: Speight, Isaiah R., Hanusa, Timothy P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037680/
https://www.ncbi.nlm.nih.gov/pubmed/32012963
http://dx.doi.org/10.3390/molecules25030570