Synthesis, Anticancer Activity, and Preliminary Pharmacokinetic Evaluation of 4,4-Disubstituted Curcuminoid 2,2-bis(Hydroxymethyl)Propionate Derivatives

Compound 1 is a curcumin di-O-2,2-bis(hydroxymethyl)propionate that shows significant in vitro and in vivo inhibitory activity against MDA-MB-231 cells with eight to ten-fold higher potency than curcumin. Here, we modified the α-position (C-4 position) of the central 1,3-diketone moiety of 1 with po...

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Detalles Bibliográficos
Autores principales: Lee, Der-Yen, Hou, Yu-Chi, Yang, Jai-Sing, Lin, Hui-Yi, Chang, Tsu-Yuan, Lee, Kuo-Hsiung, Kuo, Sheng-Chu, Hsieh, Min-Tsang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037731/
https://www.ncbi.nlm.nih.gov/pubmed/31979200
http://dx.doi.org/10.3390/molecules25030479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037731/
https://www.ncbi.nlm.nih.gov/pubmed/31979200
http://dx.doi.org/10.3390/molecules25030479

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