Synthesis of Combretastatin A-4 and 3′-Aminocombretastatin A-4 derivatives with Aminoacid Containing Pendants and Study of their Interaction with Tubulin and as Downregulators of the VEGF, hTERT and c-Myc Gene Expression

Natural product combretastatin A-4 (CA-4) and its nitrogenated analogue 3′-aminocombretastatin A-4 (AmCA-4) have shown promising antitumor activities. In this study, a range of CA-4 and AmCA-4 derivatives containing amino acid pendants have been synthesized in order to compare their biological actio...

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Detalles Bibliográficos
Autores principales: Agut, Raül, Falomir, Eva, Murga, Juan, Martín-Beltrán, Celia, Gil-Edo, Raquel, Pla, Alberto, Carda, Miguel, Marco, J. Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037732/
https://www.ncbi.nlm.nih.gov/pubmed/32033084
http://dx.doi.org/10.3390/molecules25030660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037732/
https://www.ncbi.nlm.nih.gov/pubmed/32033084
http://dx.doi.org/10.3390/molecules25030660

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