Cargando…
Sledgehammer to Scalpel: Broad Challenges to the Heart and Other Tissues Yield Specific Cellular Responses via Transcriptional Regulation of the ER-Stress Master Regulator ATF6α
There are more than 2000 transcription factors in eukaryotes, many of which are subject to complex mechanisms fine-tuning their activity and their transcriptional programs to meet the vast array of conditions under which cells must adapt to thrive and survive. For example, conditions that impair pro...
Autores principales: | Stauffer, Winston T., Arrieta, Adrian, Blackwood, Erik A., Glembotski, Christopher C. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037772/ https://www.ncbi.nlm.nih.gov/pubmed/32046286 http://dx.doi.org/10.3390/ijms21031134 |
Ejemplares similares
-
ATF6 as a Nodal Regulator of Proteostasis in the Heart
por: Glembotski, Christopher C., et al.
Publicado: (2020) -
Designing Novel Therapies to Mend Broken Hearts: ATF6 and Cardiac Proteostasis
por: Blackwood, Erik A., et al.
Publicado: (2020) -
Integrating ER and Mitochondrial Proteostasis in the Healthy and Diseased Heart
por: Arrieta, Adrian, et al.
Publicado: (2020) -
The ER Unfolded Protein Response Effector, ATF6, Reduces Cardiac Fibrosis and Decreases Activation of Cardiac Fibroblasts
por: Stauffer, Winston T., et al.
Publicado: (2020) -
ER-Specific Autophagy or ER-Phagy in Cardiac Myocytes Protects the Heart Against Doxorubicin-Induced Cardiotoxicity
por: Glembotski, Christopher C., et al.
Publicado: (2023)