Competitive Binding of Magnesium to Calcium Binding Sites Reciprocally Regulates Transamidase and GTP Hydrolysis Activity of Transglutaminase 2

Transglutaminase 2 (TG2) is a Ca(2+)-dependent enzyme, which regulates various cellular processes by catalyzing protein crosslinking or polyamination. Intracellular TG2 is activated and inhibited by Ca(2+) and GTP binding, respectively. Although aberrant TG2 activation has been implicated in the pat...

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Detalles Bibliográficos
Autores principales: Jeong, Eui Man, Lee, Ki Baek, Kim, Gi Eob, Kim, Chang Min, Lee, Jin-Haeng, Kim, Hyo-Jun, Shin, Ji-Woong, Kwon, Mee-ae, Park, Hyun Ho, Kim, In-Gyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037829/
https://www.ncbi.nlm.nih.gov/pubmed/31991788
http://dx.doi.org/10.3390/ijms21030791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037829/
https://www.ncbi.nlm.nih.gov/pubmed/31991788
http://dx.doi.org/10.3390/ijms21030791

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