A Small Number of HER2 Redirected CAR T Cells Significantly Improves Immune Response of Adoptively Transferred Mouse Lymphocytes against Human Breast Cancer Xenografts

HER2 positive JIMT-1 breast tumors are resistant to trastuzumab treatment in vitro and develop resistance to trastuzumab in vivo in SCID mice. We explored whether these resistant tumors could still be eliminated by T cells redirected by a second-generation chimeric antigen receptor (CAR) containing...

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Detalles Bibliográficos
Autores principales: Tóth, Gábor, Szöllősi, János, Abken, Hinrich, Vereb, György, Szöőr, Árpád
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038081/
https://www.ncbi.nlm.nih.gov/pubmed/32033208
http://dx.doi.org/10.3390/ijms21031039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038081/
https://www.ncbi.nlm.nih.gov/pubmed/32033208
http://dx.doi.org/10.3390/ijms21031039

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