Synthesis and Antileishmanial Activity of 1,2,4,5-Tetraoxanes against Leishmania donovani

A chemically diverse range of novel tetraoxanes was synthesized and evaluated in vitro against intramacrophage amastigote forms of Leishmania donovani. All 15 tested tetraoxanes displayed activity, with IC(50) values ranging from 2 to 45 µm. The most active tetraoxane, compound LC140, exhibited an I...

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Detalles Bibliográficos
Autores principales: Cabral, Lília I. L., Pomel, Sébastien, Cojean, Sandrine, Amado, Patrícia S. M., Loiseau, Philippe M., Cristiano, Maria L. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038143/
https://www.ncbi.nlm.nih.gov/pubmed/31979089
http://dx.doi.org/10.3390/molecules25030465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038143/
https://www.ncbi.nlm.nih.gov/pubmed/31979089
http://dx.doi.org/10.3390/molecules25030465

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