Cargando…

Synthesis and Antileishmanial Activity of 1,2,4,5-Tetraoxanes against Leishmania donovani

A chemically diverse range of novel tetraoxanes was synthesized and evaluated in vitro against intramacrophage amastigote forms of Leishmania donovani. All 15 tested tetraoxanes displayed activity, with IC(50) values ranging from 2 to 45 µm. The most active tetraoxane, compound LC140, exhibited an I...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cabral, Lília I. L., Pomel, Sébastien, Cojean, Sandrine, Amado, Patrícia S. M., Loiseau, Philippe M., Cristiano, Maria L. S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Letter
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038143/ https://www.ncbi.nlm.nih.gov/pubmed/31979089 http://dx.doi.org/10.3390/molecules25030465

Ejemplares similares

1,2,4-Trioxolane and 1,2,4,5-Tetraoxane Endoperoxides against Old-World Leishmania Parasites: In Vitro Activity and Mode of Action
por: Mendes, Andreia, et al.
Publicado: (2022)

Deciphering the mechanism of action of VP343, an antileishmanial drug candidate, in Leishmania infantum
por: Obeid, Sameh, et al.
Publicado: (2023)

Intranasal vaccine from whole Leishmania donovani antigens provides protection and induces specific immune response against visceral leishmaniasis
por: Helou, Doumet Georges, et al.
Publicado: (2021)

The Potential of 2-Substituted Quinolines as Antileishmanial Drug Candidates
por: Loiseau, Philippe M., et al.
Publicado: (2022)

Genomic and transcriptomic alterations in Leishmania donovani lines experimentally resistant to antileishmanial drugs
por: Rastrojo, Alberto, et al.
Publicado: (2018)

Enhanced Glycolysis Is Required for Antileishmanial Functions of Neutrophils Upon Infection With Leishmania donovani
por: Ohms, Mareike, et al.
Publicado: (2021)

Cinnamomum cassia exhibits antileishmanial activity against Leishmania donovani infection in vitro and in vivo
por: Afrin, Farhat, et al.
Publicado: (2019)

Sitamaquine as a putative antileishmanial drug candidate: from the mechanism of action to the risk of drug resistance
por: Loiseau, P.M., et al.
Publicado: (2011)

Leishmania donovani Impedes Antileishmanial Immunity by Suppressing Dendritic Cells via the TIM-3 Receptor
por: Akhtar, Md. Naushad, et al.
Publicado: (2022)

Alkyl-Resorcinol Derivatives as Inhibitors of GDP-Mannose Pyrophosphorylase with Antileishmanial Activities
por: Levaique, Hélène, et al.
Publicado: (2021)

Identification of Potential Antiviral Inhibitors from Hydroxychloroquine and 1,2,4,5-Tetraoxanes Analogues and Investigation of the Mechanism of Action in SARS-CoV-2
por: Ramos, Ryan S., et al.
Publicado: (2022)

Synthesis, Structure and Antileishmanial Evaluation of Endoperoxide–Pyrazole Hybrids
por: Amado, Patrícia S. M., et al.
Publicado: (2022)

The triterpenoid fraction from Trichosanthes dioica root exhibits in vitro antileishmanial effect against Leishmania donovani promastigotes
por: Bhattacharya, Sanjib, et al.
Publicado: (2013)

Oxidative Stress-Mediated Overexpression of Uracil DNA Glycosylase in Leishmania donovani Confers Tolerance against Antileishmanial Drugs
por: Mishra, Anshul, et al.
Publicado: (2018)

Cynaroside inhibits Leishmania donovani UDP-galactopyranose mutase and induces reactive oxygen species to exert antileishmanial response
por: Tabrez, Shams, et al.
Publicado: (2021)

Minor Impact of A258D Mutation on Biochemical and Enzymatic Properties of Leishmania infantum GDP-Mannose Pyrophosphorylase
por: Mao, Wei, et al.
Publicado: (2022)

Some novel antileishmanial compounds inhibit normal cell cycle progression of Leishmania donovani promastigotes and exhibits pro-oxidative potential
por: Amlabu, Wandayi Emmanuel, et al.
Publicado: (2021)

5-Phenoxy Primaquine Analogs and the Tetraoxane Hybrid as Antimalarial Agents
por: Jansongsaeng, Somruedee, et al.
Publicado: (2021)

LEISHMANIA DONOVANI IN THE PERIPHERAL BLOOD
por: Young, Charles W., et al.
Publicado: (1923)

CYP5122A1 encodes an essential sterol C4-methyl oxidase in Leishmania donovani and determines the antileishmanial activity of antifungal azoles
por: Jin, Yiru, et al.
Publicado: (2023)

Antileishmanial activity of terpenylquinones on Leishmania infantum and their effects on Leishmania topoisomerase IB
por: Pérez-Pertejo, Yolanda, et al.
Publicado: (2019)

Bioassay-based Corchorus capsularis L. leaf-derived β-sitosterol exerts antileishmanial effects against Leishmania donovani by targeting trypanothione reductase
por: Pramanik, Pijush Kanti, et al.
Publicado: (2020)

A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line
por: Jain, Surendra K., et al.
Publicado: (2012)

Leishmania Resistance to Miltefosine Associated with Genetic Marker
por: Cojean, Sandrine, et al.
Publicado: (2012)

Proteomic analysis of the secretome of Leishmania donovani
por: Silverman, J Maxwell, et al.
Publicado: (2008)

Mechanochemical Studies on Coupling of Hydrazines and Hydrazine Amides with Phenolic and Furanyl Aldehydes—Hydrazones with Antileishmanial and Antibacterial Activities
por: Kapusterynska, Anna, et al.
Publicado: (2023)

Surface antigens of Leishmania donovani promastigotes
Publicado: (1983)

Vaccine Development Against Leishmania donovani
por: Das, Amrita, et al.
Publicado: (2012)

Leishmania donovani bodies in bone marrow
por: Ali, Natasha, et al.
Publicado: (2014)

Leishmania donovani and Cutaneous Leishmaniasis, Sri Lanka
por: Siriwardana, H. V. Yamuna D., et al.
Publicado: (2007)

The identification of kala-azar and the discovery of Leishmania donovani.
por: Gibson, M E
Publicado: (1983)

Chitosan Contribution to Therapeutic and Vaccinal Approaches for the Control of Leishmaniasis
por: Loiseau, Philippe M., et al.
Publicado: (2020)

In silico analysis of a therapeutic target in Leishmania infantum: the guanosine-diphospho-D-mannose pyrophosphorylase
por: Pomel, S., et al.
Publicado: (2012)

Global genome diversity of the Leishmania donovani complex
por: Franssen, Susanne U, et al.
Publicado: (2020)

Antileishmanial Activity of 4,8-Dimethoxynaphthalenyl Chalcones on Leishmania amazonensis
por: de Santiago-Silva, Kaio Maciel, et al.
Publicado: (2022)

In vitro evaluation of antimicrobial agents on Acanthamoeba sp. and evidence of a natural resilience to amphotericin B
por: Taravaud, Alexandre, et al.
Publicado: (2017)

Genomic and Phenotypic Characterization of Experimentally Selected Resistant Leishmania donovani Reveals a Role for Dynamin-1-Like Protein in the Mechanism of Resistance to a Novel Antileishmanial Compound
por: Hefnawy, Aya, et al.
Publicado: (2022)

Leishmania donovani Develops Resistance to Drug Combinations
por: García-Hernández, Raquel, et al.
Publicado: (2012)

Hemophagocytosis in Experimental Visceral Leishmaniasis by Leishmania donovani
por: Morimoto, Ayako, et al.
Publicado: (2016)

On Transient Infections with Leishmania Donovani in Man and Animals
por: Knowles, R., et al.
Publicado: (1924)

Cannot write session to /tmp/vufind_sessions/sess_ve9ctad3uok1es8i2ljq778dpm