Design, Synthesis, and Evaluation of Acetylcholinesterase and Butyrylcholinesterase Dual-Target Inhibitors against Alzheimer’s Diseases

A series of novel compounds 6a–h, 8i–1, 10s–v, and 16a–d were synthesized and evaluated, together with the known analogs 11a–f, for their inhibitory activities towards acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The inhibitory activities of AChE and BChE were evaluated in vitro by...

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Detalles Bibliográficos
Autores principales: Guo, Yan, Yang, Hongyu, Huang, Zhongwei, Tian, Sen, Li, Qihang, Du, Chenxi, Chen, Tingkai, Liu, Yang, Sun, Haopeng, Liu, Zongliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038160/
https://www.ncbi.nlm.nih.gov/pubmed/31979317
http://dx.doi.org/10.3390/molecules25030489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038160/
https://www.ncbi.nlm.nih.gov/pubmed/31979317
http://dx.doi.org/10.3390/molecules25030489

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