Model-Informed Drug Development, Pharmacokinetic/Pharmacodynamic Cutoff Value Determination, and Antibacterial Efficacy of Benapenem against Enterobacteriaceae

Benapenem is a novel carbapenem. The objective of this study was to determine the pharmacokinetic (PK)/pharmacodynamic (PD) cutoff values and evaluate the optimal administration regimens of benapenem for the treatment of bacterial infections via PK/PD modeling and simulation. Ertapenem was used as a...

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Detalles Bibliográficos
Autores principales: Ji, Xi-wei, Xue, Feng, Kang, Zi-sheng, Zhong, Wei, Kuan, Isabelle Hui-san, Yang, Xi-ping, Zhu, Xiao, Li, Yun, Lv, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038265/
https://www.ncbi.nlm.nih.gov/pubmed/31844001
http://dx.doi.org/10.1128/AAC.01751-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038265/
https://www.ncbi.nlm.nih.gov/pubmed/31844001
http://dx.doi.org/10.1128/AAC.01751-19

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