A Subcutaneous Implant of Tenofovir Alafenamide Fumarate Causes Local Inflammation and Tissue Necrosis in Rabbits and Macaques

We describe the in vitro and in vivo evaluation of a subcutaneous reservoir implant delivering tenofovir alafenamide hemifumarate (TAF) for the prevention of HIV infection. These long-acting reservoir implants were able to deliver antiretroviral drug for over 90 days in vitro and in vivo. We evaluat...

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Detalles Bibliográficos
Autores principales: Su, Jonathan T., Simpson, Solange M., Sung, Samuel, Tfaily, Ewa Bryndza, Veazey, Ronald, Marzinke, Mark, Qiu, Jiang, Watrous, David, Widanapathirana, Lakmini, Pearson, Elizabeth, Peet, M. Melissa, Karunakaran, Dipu, Grasperge, Brooke, Dobek, Georgina, Cain, Charlette M., Hope, Thomas, Kiser, Patrick F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038301/
https://www.ncbi.nlm.nih.gov/pubmed/31871073
http://dx.doi.org/10.1128/AAC.01893-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038301/
https://www.ncbi.nlm.nih.gov/pubmed/31871073
http://dx.doi.org/10.1128/AAC.01893-19

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