Impact of mutations in DNA methylation modification genes on genome-wide methylation landscapes and downstream gene activations in pan-cancer

BACKGROUND: In cancer, mutations of DNA methylation modification genes have crucial roles for epigenetic modifications genome-wide, which lead to the activation or suppression of important genes including tumor suppressor genes. Mutations on the epigenetic modifiers could affect the enzyme activity,...

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Detalles Bibliográficos
Autores principales: Lee, Chai-Jin, Ahn, Hongryul, Jeong, Dabin, Pak, Minwoo, Moon, Ji Hwan, Kim, Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038532/
https://www.ncbi.nlm.nih.gov/pubmed/32093698
http://dx.doi.org/10.1186/s12920-020-0659-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038532/
https://www.ncbi.nlm.nih.gov/pubmed/32093698
http://dx.doi.org/10.1186/s12920-020-0659-4

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