Unexpected cell type-dependent effects of autophagy on polyglutamine aggregation revealed by natural genetic variation in C. elegans

BACKGROUND: Monogenic protein aggregation diseases, in addition to cell selectivity, exhibit clinical variation in the age of onset and progression, driven in part by inter-individual genetic variation. While natural genetic variants may pinpoint plastic networks amenable to intervention, the mechan...

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Detalles Bibliográficos
Autores principales: Alexander-Floyd, J., Haroon, S., Ying, M., Entezari, A. A., Jaeger, C., Vermulst, M., Gidalevitz, T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038566/
https://www.ncbi.nlm.nih.gov/pubmed/32093691
http://dx.doi.org/10.1186/s12915-020-0750-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038566/
https://www.ncbi.nlm.nih.gov/pubmed/32093691
http://dx.doi.org/10.1186/s12915-020-0750-5

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