HLA Heterozygote Advantage against HIV-1 Is Driven by Quantitative and Qualitative Differences in HLA Allele-Specific Peptide Presentation

Pathogen-mediated balancing selection is regarded as a key driver of host immunogenetic diversity. A hallmark for balancing selection in humans is the heterozygote advantage at genes of the human leukocyte antigen (HLA), resulting in improved HIV-1 control. However, the actual mechanism of the obser...

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Detalles Bibliográficos
Autores principales: Arora, Jatin, Pierini, Federica, McLaren, Paul J, Carrington, Mary, Fellay, Jacques, Lenz, Tobias L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038656/
https://www.ncbi.nlm.nih.gov/pubmed/31651980
http://dx.doi.org/10.1093/molbev/msz249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038656/
https://www.ncbi.nlm.nih.gov/pubmed/31651980
http://dx.doi.org/10.1093/molbev/msz249

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