Unique repression domains of Pumilio utilize deadenylation and decapping factors to accelerate destruction of target mRNAs

Pumilio is an RNA-binding protein that represses a network of mRNAs to control embryogenesis, stem cell fate, fertility and neurological functions in Drosophila. We sought to identify the mechanism of Pumilio-mediated repression and find that it accelerates degradation of target mRNAs, mediated by t...

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Detalles Bibliográficos
Autores principales: Arvola, René M, Chang, Chung-Te, Buytendorp, Joseph P, Levdansky, Yevgen, Valkov, Eugene, Freddolino, Peter L, Goldstrohm, Aaron C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038932/
https://www.ncbi.nlm.nih.gov/pubmed/31863588
http://dx.doi.org/10.1093/nar/gkz1187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038932/
https://www.ncbi.nlm.nih.gov/pubmed/31863588
http://dx.doi.org/10.1093/nar/gkz1187

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