Cargando…

Unique repression domains of Pumilio utilize deadenylation and decapping factors to accelerate destruction of target mRNAs

Pumilio is an RNA-binding protein that represses a network of mRNAs to control embryogenesis, stem cell fate, fertility and neurological functions in Drosophila. We sought to identify the mechanism of Pumilio-mediated repression and find that it accelerates degradation of target mRNAs, mediated by t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Arvola, René M, Chang, Chung-Te, Buytendorp, Joseph P, Levdansky, Yevgen, Valkov, Eugene, Freddolino, Peter L, Goldstrohm, Aaron C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038932/ https://www.ncbi.nlm.nih.gov/pubmed/31863588 http://dx.doi.org/10.1093/nar/gkz1187

Ejemplares similares

Global translation inhibition yields condition-dependent de-repression of ribosome biogenesis mRNAs
por: Cheng, Ze, et al.
Publicado: (2019)

A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5′–3′ messenger RNA decay
por: Chang, Chung-Te, et al.
Publicado: (2019)

Genetic context effects can override canonical cis regulatory elements in Escherichia coli
por: Scholz, Scott A, et al.
Publicado: (2022)

m(6)A and YTHDF proteins contribute to the localization of select neuronal mRNAs
por: Flamand, Mathieu N, et al.
Publicado: (2022)

Modes of TAL effector-mediated repression
por: Werner, Jeannette, et al.
Publicado: (2014)

A subset of replication-dependent histone mRNAs are expressed as polyadenylated RNAs in terminally differentiated tissues
por: Lyons, Shawn M., et al.
Publicado: (2016)

Gene repression by minimal lac loops in vivo
por: Bond, Laura M., et al.
Publicado: (2010)

Mechanism of promoter repression by Lac repressor–DNA loops
por: Becker, Nicole A., et al.
Publicado: (2013)

TIP60 represses activation of endogenous retroviral elements
por: Rajagopalan, Deepa, et al.
Publicado: (2018)

The autoregulator Aca2 mediates anti-CRISPR repression
por: Birkholz, Nils, et al.
Publicado: (2019)

Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation
por: Raisch, Tobias, et al.
Publicado: (2019)

Long 3′-UTRs target wild-type mRNAs for nonsense-mediated mRNA decay in Saccharomyces cerevisiae
por: Kebaara, Bessie W., et al.
Publicado: (2009)

SAYP and Brahma are important for ‘repressive’ and ‘transient’ Pol II pausing
por: Vorobyeva, Nadezhda E., et al.
Publicado: (2012)

Estrogen represses gene expression through reconfiguring chromatin structures
por: Osmanbeyoglu, Hatice Ulku, et al.
Publicado: (2013)

Musashi mediates translational repression of the Drosophila hypoxia inducible factor
por: Bertolin, Agustina P., et al.
Publicado: (2016)

DNA residence time is a regulatory factor of transcription repression
por: Clauß, Karen, et al.
Publicado: (2017)

DNA sequence encoded repression of rRNA gene transcription in chromatin
por: Felle, Max, et al.
Publicado: (2010)

Widespread repression of anti-CRISPR production by anti-CRISPR-associated proteins
por: Shehreen, Saadlee, et al.
Publicado: (2022)

The post-transcriptional trans-acting regulator, TbZFP3, co-ordinates transmission-stage enriched mRNAs in Trypanosoma brucei
por: Walrad, Pegine B., et al.
Publicado: (2012)

Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins
por: Cridge, Andrew G., et al.
Publicado: (2010)

hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling
por: Roy, Rajat, et al.
Publicado: (2014)

A conserved domain of Drosophila RNA-binding protein Pumilio interacts with multiple CCR4–NOT deadenylase complex subunits to repress target mRNAs
por: Haugen, Rebecca J., et al.
Publicado: (2022)

Gcn2 eIF2α kinase mediates combinatorial translational regulation through nucleotide motifs and uORFs in target mRNAs
por: Chikashige, Yuji, et al.
Publicado: (2020)

MBNL1 and PTB cooperate to repress splicing of Tpm1 exon 3
por: Gooding, Clare, et al.
Publicado: (2013)

Bacterial promoter repression by DNA looping without protein–protein binding competition
por: Becker, Nicole A., et al.
Publicado: (2014)

MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma
por: Lodrini, Marco, et al.
Publicado: (2013)

Repression of class I transcription by cadmium is mediated by the protein phosphatase 2A
por: Zhou, Lei, et al.
Publicado: (2013)

Antisense transcriptional interference mediates condition-specific gene repression in budding yeast
por: Nevers, Alicia, et al.
Publicado: (2018)

Histone chaperone FACT represses retrotransposon MERVL and MERVL-derived cryptic promoters
por: Chen, Fuquan, et al.
Publicado: (2020)

A cascade of transcriptional repression determines sexual commitment and development in Plasmodium falciparum
por: Shang, Xiaomin, et al.
Publicado: (2021)

Antisense-mediated repression of SAGA-dependent genes involves the HIR histone chaperone
por: Soudet, Julien, et al.
Publicado: (2022)

Crol contributes to PRE-mediated repression and Polycomb group proteins recruitment in Drosophila
por: Erokhin, Maksim, et al.
Publicado: (2023)

DNA elements tether canonical Polycomb Repressive Complex 1 to human genes
por: Barrasa, Juan I, et al.
Publicado: (2023)

Sumoylation of LAP1 is involved in the HDAC4-mediated repression of COX-2 transcription
por: Wang, Wen-Ling, et al.
Publicado: (2008)

BIM promoter directly targeted by EBNA3C in polycomb-mediated repression by EBV
por: Paschos, Kostas, et al.
Publicado: (2012)

Evidence that TSC2 acts as a transcription factor and binds to and represses the promoter of Epiregulin
por: Pradhan, Shalmali Avinash, et al.
Publicado: (2014)

macroH2A1 histone variant represses rDNA transcription
por: Cong, Rong, et al.
Publicado: (2014)

The interaction of ω(2) with the RNA polymerase β’ subunit functions as an activation to repression switch
por: Volante, Andrea, et al.
Publicado: (2015)

INO80 represses osmostress induced gene expression by resetting promoter proximal nucleosomes
por: Klopf, Eva, et al.
Publicado: (2017)

SIRT7 mediates L1 elements transcriptional repression and their association with the nuclear lamina
por: Vazquez, Berta N, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_52keebbb2e5fui24pb68egvsjr