The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5′ cap modulates protein expression in living cells

7-Methylguanosine 5′ cap on mRNA is necessary for efficient protein expression in vitro and in vivo. Recent studies revealed structural diversity of endogenous mRNA caps, which carry different 5′-terminal nucleotides and additional methylations (2′-O-methylation and m(6)A). Currently available 5′-ca...

Descripción completa

Detalles Bibliográficos
Autores principales: Sikorski, Pawel J, Warminski, Marcin, Kubacka, Dorota, Ratajczak, Tomasz, Nowis, Dominika, Kowalska, Joanna, Jemielity, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
NAR Breakthrough Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038993/
https://www.ncbi.nlm.nih.gov/pubmed/31984425
http://dx.doi.org/10.1093/nar/gkaa032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038993/
https://www.ncbi.nlm.nih.gov/pubmed/31984425
http://dx.doi.org/10.1093/nar/gkaa032

Ejemplares similares