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The liquid state of FG-nucleoporins mimics permeability barrier properties of nuclear pore complexes

Nuclear pore complexes (NPCs) regulate all cargo traffic across the nuclear envelope. The transport conduit of NPCs is highly enriched in disordered phenylalanine/glycine-rich nucleoporins (FG-Nups), which form a permeability barrier of still elusive and highly debated molecular structure. Here we p...

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Detalles Bibliográficos
Autores principales: Celetti, Giorgia, Paci, Giulia, Caria, Joana, VanDelinder, Virginia, Bachand, George, Lemke, Edward A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039189/
https://www.ncbi.nlm.nih.gov/pubmed/31723007
http://dx.doi.org/10.1083/jcb.201907157