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PQLC2 recruits the C9orf72 complex to lysosomes in response to cationic amino acid starvation
The C9orf72 protein is required for normal lysosome function. In support of such functions, C9orf72 forms a heterotrimeric complex with SMCR8 and WDR41 that is recruited to lysosomes when amino acids are scarce. These properties raise questions about the identity of the lysosomal binding partner of...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039192/ https://www.ncbi.nlm.nih.gov/pubmed/31851326 http://dx.doi.org/10.1083/jcb.201906076 |