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PQLC2 recruits the C9orf72 complex to lysosomes in response to cationic amino acid starvation

The C9orf72 protein is required for normal lysosome function. In support of such functions, C9orf72 forms a heterotrimeric complex with SMCR8 and WDR41 that is recruited to lysosomes when amino acids are scarce. These properties raise questions about the identity of the lysosomal binding partner of...

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Detalles Bibliográficos
Autores principales: Amick, Joseph, Tharkeshwar, Arun Kumar, Talaia, Gabriel, Ferguson, Shawn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039192/
https://www.ncbi.nlm.nih.gov/pubmed/31851326
http://dx.doi.org/10.1083/jcb.201906076