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PQLC2 recruits the C9orf72 complex to lysosomes in response to cationic amino acid starvation
The C9orf72 protein is required for normal lysosome function. In support of such functions, C9orf72 forms a heterotrimeric complex with SMCR8 and WDR41 that is recruited to lysosomes when amino acids are scarce. These properties raise questions about the identity of the lysosomal binding partner of...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039192/ https://www.ncbi.nlm.nih.gov/pubmed/31851326 http://dx.doi.org/10.1083/jcb.201906076 |