Relief of talin autoinhibition triggers a force-independent association with vinculin

Talin, vinculin, and paxillin are core components of the dynamic link between integrins and actomyosin. Here, we study the mechanisms that mediate their activation and association using a mitochondrial-targeting assay, structure-based mutants, and advanced microscopy. As expected, full-length vincul...

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Detalles Bibliográficos
Autores principales: Atherton, Paul, Lausecker, Franziska, Carisey, Alexandre, Gilmore, Andrew, Critchley, David, Barsukov, Igor, Ballestrem, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039207/
https://www.ncbi.nlm.nih.gov/pubmed/31816055
http://dx.doi.org/10.1083/jcb.201903134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039207/
https://www.ncbi.nlm.nih.gov/pubmed/31816055
http://dx.doi.org/10.1083/jcb.201903134

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