Gene expression amplification by nuclear speckle association

Many active genes reproducibly position near nuclear speckles, but the functional significance of this positioning is unknown. Here we show that HSPA1B BAC transgenes and endogenous Hsp70 genes turn on 2–4 min after heat shock (HS), irrespective of their distance to speckles. However, both total HSP...

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Detalles Bibliográficos
Autores principales: Kim, Jiah, Venkata, Neha Chivukula, Hernandez Gonzalez, Gabriela Andrea, Khanna, Nimish, Belmont, Andrew S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039209/
https://www.ncbi.nlm.nih.gov/pubmed/31757787
http://dx.doi.org/10.1083/jcb.201904046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039209/
https://www.ncbi.nlm.nih.gov/pubmed/31757787
http://dx.doi.org/10.1083/jcb.201904046

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