Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain

Glucose homeostasis and growth essentially depend on the hormone insulin engaging its receptor. Despite biochemical and structural advances, a fundamental contradiction has persisted in the current understanding of insulin ligand–receptor interactions. While biochemistry predicts two distinct insuli...

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Detalles Bibliográficos
Autores principales: Gutmann, Theresia, Schäfer, Ingmar B., Poojari, Chetan, Brankatschk, Beate, Vattulainen, Ilpo, Strauss, Mike, Coskun, Ünal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039211/
https://www.ncbi.nlm.nih.gov/pubmed/31727777
http://dx.doi.org/10.1083/jcb.201907210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039211/
https://www.ncbi.nlm.nih.gov/pubmed/31727777
http://dx.doi.org/10.1083/jcb.201907210

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