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CD2AP links actin to PI3 kinase activity to extend epithelial cell height and constrain cell area
Maintaining the correct ratio of apical, basal, and lateral membrane domains is important for epithelial physiology. Here, we show that CD2AP is a critical determinant of epithelial membrane proportions. Depletion of CD2AP or phosphoinositide 3-kinase (PI3K) inhibition results in loss of F-actin and...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Rockefeller University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039212/ https://www.ncbi.nlm.nih.gov/pubmed/31723006 http://dx.doi.org/10.1083/jcb.201812087 |