Topoisomerase II SUMOylation activates a metaphase checkpoint via Haspin and Aurora B kinases

Topoisomerase II (Topo II) is essential for mitosis since it resolves sister chromatid catenations. Topo II dysfunction promotes aneuploidy and drives cancer. To protect from aneuploidy, cells possess mechanisms to delay anaphase onset when Topo II is perturbed, providing additional time for decaten...

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Detalles Bibliográficos
Autores principales: Pandey, Nootan, Keifenheim, Daniel, Yoshida, Makoto Michael, Hassebroek, Victoria A., Soroka, Caitlin, Azuma, Yoshiaki, Clarke, Duncan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039214/
https://www.ncbi.nlm.nih.gov/pubmed/31712254
http://dx.doi.org/10.1083/jcb.201807189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039214/
https://www.ncbi.nlm.nih.gov/pubmed/31712254
http://dx.doi.org/10.1083/jcb.201807189

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