A transient amphipathic helix in the prodomain of PCSK9 facilitates binding to low-density lipoprotein particles

Proprotein convertase subtilisin/kexin type-9 (PCSK9) is a ligand of low-density lipoprotein (LDL) receptor (LDLR) that promotes LDLR degradation in late endosomes/lysosomes. In human plasma, 30–40% of PCSK9 is bound to LDL particles; however, the physiological significance of this interaction remai...

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Detalles Bibliográficos
Autores principales: Sarkar, Samantha K., Foo, Alexander C. Y., Matyas, Angela, Asikhia, Ikhuosho, Kosenko, Tanja, Goto, Natalie K., Vergara-Jaque, Ariela, Lagace, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Lipids
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039556/
https://www.ncbi.nlm.nih.gov/pubmed/31949048
http://dx.doi.org/10.1074/jbc.RA119.010221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039556/
https://www.ncbi.nlm.nih.gov/pubmed/31949048
http://dx.doi.org/10.1074/jbc.RA119.010221

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