Moonlighting matrix metalloproteinase substrates: Enhancement of proinflammatory functions of extracellular tyrosyl-tRNA synthetase upon cleavage

Tyrosyl-tRNA synthetase ligates tyrosine to its cognate tRNA in the cytoplasm, but it can also be secreted through a noncanonical pathway. We found that extracellular tyrosyl-tRNA synthetase (YRS) exhibited proinflammatory activities. In addition to acting as a monocyte/macrophage chemoattractant, Y...

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Detalles Bibliográficos
Autores principales: Jobin, Parker G., Solis, Nestor, Machado, Yoan, Bell, Peter A., Rai, Simran K., Kwon, Nam Hoon, Kim, Sunghoon, Overall, Christopher M., Butler, Georgina S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039567/
https://www.ncbi.nlm.nih.gov/pubmed/31771979
http://dx.doi.org/10.1074/jbc.RA119.010486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039567/
https://www.ncbi.nlm.nih.gov/pubmed/31771979
http://dx.doi.org/10.1074/jbc.RA119.010486

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