Discovering the chloride pathway in the CFTR channel

Cystic fibrosis (CF), a lethal monogenic disease, is caused by pathogenic variants of the CFTR chloride channel. The majority of CF mutations affect protein folding and stability leading overall to diminished apical anion conductance of epithelial cells. The recently published cryo-EM structures of...

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Detalles Bibliográficos
Autores principales: Farkas, Bianka, Tordai, Hedvig, Padányi, Rita, Tordai, Attila, Gera, János, Paragi, Gábor, Hegedűs, Tamás
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039865/
https://www.ncbi.nlm.nih.gov/pubmed/31327045
http://dx.doi.org/10.1007/s00018-019-03211-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039865/
https://www.ncbi.nlm.nih.gov/pubmed/31327045
http://dx.doi.org/10.1007/s00018-019-03211-4

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