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Discovering the chloride pathway in the CFTR channel
Cystic fibrosis (CF), a lethal monogenic disease, is caused by pathogenic variants of the CFTR chloride channel. The majority of CF mutations affect protein folding and stability leading overall to diminished apical anion conductance of epithelial cells. The recently published cryo-EM structures of...
Autores principales: | Farkas, Bianka, Tordai, Hedvig, Padányi, Rita, Tordai, Attila, Gera, János, Paragi, Gábor, Hegedűs, Tamás |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039865/ https://www.ncbi.nlm.nih.gov/pubmed/31327045 http://dx.doi.org/10.1007/s00018-019-03211-4 |
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