Altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomas

Uterine leiomyomas (fibroids) are a major source of gynecologic morbidity in reproductive age women and are characterized by the excessive deposition of a disorganized extracellular matrix, resulting in rigid benign tumors. Although down regulation of the transcription factor AP-1 is highly prevalen...

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Detalles Bibliográficos
Autores principales: Moyo, Mthabisi B., Parker, J. Brandon, Chakravarti, Debabrata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040020/
https://www.ncbi.nlm.nih.gov/pubmed/32094355
http://dx.doi.org/10.1038/s41467-020-14701-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040020/
https://www.ncbi.nlm.nih.gov/pubmed/32094355
http://dx.doi.org/10.1038/s41467-020-14701-6

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