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Thermodynamic, Spatial and Methodological Considerations for the Manufacturing of Therapeutic Polymer Nanoparticles
PURPOSE: Evaluate fundamental parameters that dictate the effectiveness of drug loading. METHODS: A model water-soluble drug lacking ionizable groups, pirfenidone (PFD), was encapsulated through nanoprecipitation in poly(ethylene glycol)-poly(lactic acid) (PEG-PLA)-poly(lactic-co-glycolic acid) (PLG...
Autores principales: | Maslanka Figueroa, Sara, Fleischmann, Daniel, Beck, Sebastian, Goepferich, Achim |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040083/ https://www.ncbi.nlm.nih.gov/pubmed/32095934 http://dx.doi.org/10.1007/s11095-020-2783-4 |
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