Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD

BACKGROUND: The C9ORF72 hexanucleotide repeat expansion is the most common known genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two fatal age-related neurodegenerative diseases. The C9ORF72 expansion encodes five dipeptide repeat proteins (DPRs) that are prod...

Descripción completa

Detalles Bibliográficos
Autores principales: Andrade, Nadja S., Ramic, Melina, Esanov, Rustam, Liu, Wenjun, Rybin, Mathew J., Gaidosh, Gabriel, Abdallah, Abbas, Del’Olio, Samuel, Huff, Tyler C., Chee, Nancy T., Anatha, Sadhana, Gendron, Tania F., Wahlestedt, Claes, Zhang, Yanbin, Benatar, Michael, Mueller, Christian, Zeier, Zane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041170/
https://www.ncbi.nlm.nih.gov/pubmed/32093728
http://dx.doi.org/10.1186/s13024-020-00365-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041170/
https://www.ncbi.nlm.nih.gov/pubmed/32093728
http://dx.doi.org/10.1186/s13024-020-00365-9

Ejemplares similares